Home Journals Cardiovascular Considerations for the Internist and Hospitalist in the COVID-19 Era

Cardiovascular Considerations for the Internist and Hospitalist in the COVID-19 Era

 Drug-induced QT interval prolongation and torsades de pointes

Chloroquine, hydroxychloroquine with or without azithromycin and other antiviral medications are purported to benefit COVID-19 patients. These medications are relatively weak inhibitors of cardiac potassium channels (mainly Ikr) responsible for repolarization; when used alone in healthy patients result in only minor QT-prolongation. Chloroquine has been used for malaria prophylaxis worldwide and drug-induced torsades de pointes and life-threatening ventricular tachyarrhythmias are rare in these patients, even with prolonged use.,

  • Haeusler IL
  • Chan XHS
  • Guerin PJ
  • White NJ
The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review.